3/16/2023 0 Comments Netspot logoNo uptake occurs in the cerebral cortex or heart and low uptake occurs in thymus and lung. Distribution: Ga 68 dotatate distributes in all SSTR 2-expressing organs (e.g., pituitary, thyroid, spleen, adrenals, kidney, pancreas, prostate, liver, salivary glands).MOA: Ga 68 dotatate has affinity for somatostatin subtype 2 receptors (SSTR 2) and binds to cells that express somatostatin receptors, including malignant cells which overexpress SSTR 2 receptors.Mechanism of Action (MOA), General Pharmacokinetics (PK) and Pharmacodynamics (PD) of Ga 68 dotatate The uptake may need to be confirmed by histopathology or other assessments. thyroid disease or subacute inflammation) or might occur as a normal physiologic variant (e.g. Increased uptake might also be seen in other pathologic conditions (e.g. However, uptake can also be seen in a variety of other tumor types (e.g. The uptake of Ga 68 dotatate reflects the level of somatostatin receptor density in NETs. Patients should drink as much water as possible prior to administration of Ga 68 dotatate, and void frequently during the first hours following administration to reduce radiation exposure. Administer Ga 68 dotatate as a single injection (bolus). The approved recommended amount of radioactivity to be administered for PET Imaging in adults or pediatric patients is 2 MBq/kg (0.054 mCi/kg up to 200 MBq (5.4 mCi)). NETSPOT, after radiolabeling with Ga 68, is indicated for use with positron emission tomography (PET) imaging, for the localization of somatostatin receptor positive neuroendocrine tumors (NETs) in adult and pediatric patients. Food and Drug Administration (FDA) approved NETSPOT (kit for the preparation of gallium Ga 68 dotatate injection), a radioactive diagnostic agent. FDA Approves NETSPOT (kit for preparation of gallium Ga 68 dotatate injection) for Intravenous Use
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